Yea, but the beautiful thing about this map is, Germany and Italy are two spaces away from each other.
Odds are, if one can be counter attacked, then so can the other but neither can just run infantry from one to the other without tanks.
42 will give you more of the “typical” A&A scenario (Germany starts deep in Russia, Japan is at its historical apex, etc.).
41 will give you a new experience, where the Axis haven’t really started expanding yet, but are tremendously strong compared to the Allies.
If you’re all around the same skill level, play 42. If you have a mix of stronger and poorer players, play 41 with Objectives Off and have the stronger players take the Axis. Axis are stronger in AA50 but harder to play, so the learning curve should be enough to keep the stronger players on their toes.
Good luck with your game!